Diethylpropion is a prescription medication that works as an appetite suppressant to help with weight loss. It acts directly on the brain’s satiety center to reduce hunger, helping people eat fewer calories throughout the day and promoting gradual weight reduction.
In the United States, diethylpropion hydrochloride is approved by the FDA for short-term use as part of a weight loss plan that includes a low-calorie diet and regular physical activity. It is typically prescribed for people who are obese or overweight and have not successfully lost weight through diet and exercise alone.
Because diethylpropion can cause side effects and may lead to dependence, it should only be used under close medical supervision and for a limited period of time, usually up to 12 weeks. Anyone considering weight loss medication should consult an endocrinologist or other healthcare provider to determine whether diethylpropion is an appropriate option.
What it is used for
Diethylpropion is indicated for short-term weight management in people with obesity or those who are overweight (BMI over 30 kg/m²). It is most effective when used alongside a calorie-controlled diet and regular exercise.
This medication is intended only for temporary use. Long-term weight management should focus on sustainable lifestyle changes, such as balanced nutrition and physical activity.
How to take
The dosage and administration of diethylpropion depend on the formulation prescribed. Treatment duration should not exceed 12 weeks, as prolonged use can increase the risk of dependence and side effects.
Typical adult doses
Immediate-release tablets (25 mg):
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Take one 25 mg tablet three times daily, about one hour before meals.
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The last dose should be taken 4 to 6 hours before bedtime to avoid insomnia.
Extended-release tablets (75 mg):
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Take one 75 mg tablet once daily, usually mid-morning.
If a dose is missed, it should be taken as soon as remembered. Do not take a double dose to make up for the missed one.
Dosage may be adjusted by a healthcare provider based on individual needs. Treatment should always be supervised by a qualified medical professional.
Possible side effects
The most common side effects of diethylpropion include:
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Heart palpitations or rapid heartbeat
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Chest pain
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Agitation, nervousness, or insomnia
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Dry mouth or altered taste
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Depression or headache
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Nausea, vomiting, or stomach pain
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Decreased libido or irregular menstruation
Other possible side effects may include:
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Increased blood pressure
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Pulmonary hypertension
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Dizziness, drowsiness, or vertigo
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Weakness, fainting, or confusion
Allergic reactions may also occur, causing symptoms like itching, redness, or small blisters on the skin. If this happens, medical attention should be sought immediately.
When not to use
Diethylpropion should not be used by children under 12 years old, or by women who are pregnant or breastfeeding.
It is also contraindicated for people with:
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Hyperthyroidism
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Glaucoma
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Arteriosclerosis
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Agitation or psychosis
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Myasthenia gravis
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Cardiovascular disease
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Cerebral ischemia
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Pulmonary hypertension
This medication should not be used by people with a history of substance abuse or those currently taking monoamine oxidase inhibitors (MAOIs) or certain antihypertensive drugs.
People with diabetes who use insulin or metformin may need dose adjustments while taking diethylpropion.
FDA-approved alternatives
For those looking for safer, longer-term weight loss options, the following FDA-approved medications may be prescribed under medical supervision:
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Phentermine (Adipex-P, Lomaira)
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Orlistat (Xenical, Alli)
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Naltrexone-bupropion (Contrave)
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Liraglutide (Saxenda)
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Semaglutide (Wegovy)
These alternatives are selected based on each person’s medical condition, weight loss goals, and response to previous treatments. Always consult a healthcare provider before starting any prescription medication for weight loss.