Natazia: Why It's Used, How to Take It & Side Effects

Natazia is a prescription birth control pill used to prevent pregnancy by stopping ovulation and thickening cervical mucus. It also causes changes in the uterine lining to further reduce the chances of fertilization and implantation.

This unique contraceptive pack contains 28 colored tablets that deliver varying doses of hormones or inactive ingredients. Most pills contain active hormones, while the final two are inactive placeholders that do not contain any medication.

To ensure maximum effectiveness, you should follow your gynecologist's instructions and start the pack on the first day of your period. You can also transition to Natazia immediately after finishing a previous birth control pack as directed by a healthcare provider.

Woman taking birth control

What it is used for

Natazia is primarily indicated for:

  • Preventing pregnancy

  • Treating heavy or prolonged menstrual bleeding

  • Reducing the risk of anemia and relieving menstrual cramps associated with heavy periods

These additional benefits are possible because the active tablets contain two specific hormones, estradiol valerate and dienogest. These hormones work together to regulate the menstrual cycle while providing effective contraception.

It is important to remember that Natazia does not protect against sexually transmitted infections (STIs). You should always use a condom during sexual activity to reduce the risk of contracting or spreading STIs.

How to take

Natazia should be taken by mouth with a small amount of water once a day at the same time. Follow the arrows on the blister pack to ensure you are taking the tablets in the correct order.

The 28-day regimen consists of:

  • 2 dark yellow tablets containing 3 mg of estradiol valerate

  • 5 medium red tablets containing 2 mg of estradiol valerate and 2 mg of dienogest

  • 17 light yellow tablets containing 2 mg of estradiol valerate and 3 mg of dienogest

  • 2 dark red tablets containing 1 mg of estradiol valerate

  • 2 white inactive tablets that do not contain any hormones

Each pack includes a set of 7 adhesive strips labeled with the days of the week to help you keep track of your schedule.

Place the strip that starts with your first day of use over the top of the pack so that the correct day aligns with tablet number 1.

Follow the direction of the arrows until all 28 tablets have been consumed.

Once you finish a pack of Natazia, start the next pack immediately without taking a break between them.

How to start treatment

The way you begin taking Natazia depends on whether you are currently using another form of birth control.

To start Natazia properly, follow these general guidelines:

Previous contraceptive method How to start Natazia
No previous hormonal contraceptive Take the first tablet on the first day of your menstrual cycle (the first day of your period).
Switching from a different combined pill Begin Natazia the day after you take the last active pill from your previous pack.
Switching from a vaginal ring or skin patch Start Natazia on the day the ring or patch is removed, or as advised by your doctor.
Switching from a mini-pill (progestin-only) You may start Natazia at any time during your mini-pill pack.
Switching from an injection, implant, or IUD Start Natazia on the day your next injection is due or the day your implant or IUD is removed. Use a backup method, like condoms, for the first 9 days.

If you are already using Natazia, start your new pack the day after you finish the current one. Do not wait for your bleeding to stop before beginning the next cycle of pills.

Possible side effects

The most common side effects associated with Natazia include migraines, nausea, breast tenderness, and unexpected spotting or uterine bleeding. Some users may also experience mood swings, depression, or a decrease in sex drive.

While very rare, there is an increased risk of developing blood clots in the veins or arteries, such as thrombosis.

Who should not take it

Natazia should not be used by women who have any of the following conditions:

  • Suspected or confirmed pregnancy

  • Currently breastfeeding

  • Unexplained or undiagnosed vaginal bleeding

  • A current or past history of blood clots, pulmonary embolism, or deep vein thrombosis

  • A history of heart attack, stroke, or liver disease

  • Severe kidney failure or acute liver disease

  • Uncontrolled high blood pressure or chest pain (angina)

  • Diabetes that has caused blood vessel damage

Additionally, Natazia is not recommended for those with a history of migraines with aura or a diagnosis of breast, uterine, cervical, or vaginal cancer.

This medication should also be avoided by anyone with a known allergy to estradiol valerate, dienogest, or any other ingredients listed in the pill.