Prazosin is an alpha-blocker medication used to treat high blood pressure. It works by relaxing blood vessels, allowing blood to flow more easily, which helps reduce blood pressure levels.
This medication can be taken alone or together with other antihypertensive drugs or diuretics to achieve better blood pressure control, as prescribed by a cardiologist.
Prazosin is available in the United States under the brand name Minipress SR and is approved for prescription use. It is important to consult a cardiologist to evaluate your treatment and determine whether prazosin is suitable for your condition.
Indications for use
Prazosin is indicated for the treatment of primary or secondary hypertension. It can be prescribed alone or in combination with other medications that help lower blood pressure and prevent complications such as stroke or heart attack.
In addition to treating high blood pressure, prazosin may also be prescribed off-label for certain conditions, including post-traumatic stress disorder (PTSD), benign prostatic hyperplasia (BPH), and Raynaud’s disease, depending on medical guidance. Its main approved use, however, remains the management of high blood pressure.
How to take prazosin
Prazosin capsules should be swallowed whole with a small amount of water. They can be taken at any time of the day, preferably with food. It is usually recommended to take the medication at night to help reduce the risk of dizziness or fainting when standing up, known as orthostatic hypotension.
The usual starting dose for adults is 1 mg once a day for the first 3 to 7 days. The doctor may gradually increase the dose over several days until reaching the appropriate maintenance dose, up to a maximum of 20 mg per day, depending on how the body responds and tolerates the medication.
Possible side effects
The most common side effects of prazosin include:
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Stomach pain
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Nausea or vomiting
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Diarrhea or constipation
Other possible side effects may include:
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Dizziness or lightheadedness
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Fatigue or weakness
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Headache
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Nervousness or depression
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Drowsiness
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Palpitations
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Fluid retention
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Increased urination
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Skin rash or blisters
If you experience severe dizziness, fainting, or swelling in your hands or feet, seek medical attention promptly.
Who should not take prazosin
Prazosin should not be used by people who are allergic to it or any of its ingredients.
It is also not recommended for:
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Children under 12 years old
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Pregnant or breastfeeding women, unless directed by a doctor
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People undergoing eye surgery, especially cataract surgery, due to the risk of intraoperative floppy iris syndrome
Individuals who take other blood pressure medications or have conditions such as Raynaud’s disease or heart problems should inform their doctor before taking prazosin.