Losartan: Uses, How to Take It (by Condition) & Side Effects

Key points
  • Losartan is primarily used to treat high blood pressure and heart failure by relaxing blood vessels to improve overall blood flow.
  • This medication can protect kidney function in patients with type 2 diabetes and reduces the risk of stroke in patients with hypertension.
  • Common side effects include dizziness and headaches, and the medication must not be used during pregnancy or stopped without medical advice.

Losartan is a prescription medication used to manage high blood pressure and treat heart failure. By helping blood vessels dilate, it improves blood flow and reduces the overall workload on the heart.

This medication is commonly available in 25 mg and 50 mg tablets. You can find it as the generic losartan potassium or under the brand name Cozaar.

You should only take losartan under the direct supervision of a cardiologist. Never stop taking this medication or switch to an alternative without first consulting your healthcare provider.

Woman holding pill and looking up information

Indications for use

A cardiologist may prescribe losartan for the following health concerns:

  • Treating high blood pressure (hypertension).

  • Reducing the risk of stroke, heart attack, and other cardiovascular issues in patients with hypertension and left ventricular hypertrophy.

  • Managing symptoms of heart failure.

  • Protecting kidney function and slowing the progression of renal disease in patients with type 2 diabetes and proteinuria.

Losartan potassium works by blocking the action of angiotensin II, a natural substance in the body that causes blood vessels to tighten. By inhibiting this enzyme, the medication allows blood vessels to relax, which lowers blood pressure.

In some cases, doctors may prescribe losartan alongside other medications, such as amlodipine or hydrochlorothiazide. These combinations help patients reach their blood pressure goals and improve their overall quality of life.

Can losartan cause cancer?

There is currently no definitive evidence proving that losartan causes cancer.

Concerns have been raised regarding trace amounts of impurities called nitrosamines found in some batches of the medication, which could potentially increase cancer risk over long periods. However, the exact level of risk remains unknown.

It is vital not to stop your treatment abruptly without medical advice. Discontinuing blood pressure medication can lead to severe health emergencies, including heart attacks or strokes.

If you have concerns, schedule a follow-up appointment with your prescribing physician to discuss your treatment plan or explore alternative medications.

How to take it

Losartan is taken orally with a glass of water and can be used with or without food.

Most patients take their dose in the morning, though it can be taken at any time of day as long as you remain consistent, since the effects last for 24 hours.

Your specific dosage will be determined by a primary care physician or cardiologist. They will base your prescription on your medical goals, symptoms, age, other medications, and how your body responds to the drug.

Losartan 50 mg

Typical dosages for adults using 25 mg or 50 mg tablets are outlined below:

Indication Typical dosage
High blood pressure 50 mg once daily. A doctor may increase this to 100 mg once daily based on your results.
Heart failure Usually starts at 12.5 mg once daily. This may be gradually increased to 50 mg once daily over several weeks.
Cardiovascular risk reduction 50 mg once daily. A doctor may increase this to 100 mg or add hydrochlorothiazide if needed.
Kidney protection (type 2 diabetes) 50 mg once daily. The dose may be increased to 100 mg depending on your blood pressure response.

It can take 3 to 6 weeks of consistent use to reach the full blood pressure lowering effect. Do not alter your dose or stop the medication unless instructed by your doctor.

Possible side effects

The most frequent side effects associated with losartan include dizziness, low blood pressure, headaches, or changes in heart rhythm.

Other potential symptoms may include shortness of breath, extreme fatigue, lightheadedness when standing up (orthostatic hypotension), low blood sugar, and vertigo.

Does losartan cause weight loss or gain?

Losartan is not known to cause weight gain. In rare instances, localized fluid retention might occur, which can create the temporary sensation of weighing more, but the drug does not increase body fat.

On rare occasions, the medication may cause nausea or a loss of appetite, leading to minor weight loss in some individuals. However, losartan is not a weight loss drug and should never be used for that purpose.

Always use this medication under medical supervision so a professional can monitor your side effects and help determine the cause of any weight fluctuations.

Who should not take it

Losartan potassium is not recommended for individuals with a known allergy to the active ingredient or any of the inactive components in the tablet.

Additionally, this medication should not be used by those who are pregnant or breastfeeding. It is also contraindicated for individuals with significant liver or kidney issues, or those taking medications that contain aliskiren.