The worst side effects of amlodipine are severe leg or ankle swelling, a strong drop in blood pressure that can cause fainting, serious allergic reactions with breathing trouble or hives, and rare liver problems signaled by yellow skin or eyes. These are uncommon, but they need urgent medical attention if they occur.
Severe swelling happens because this medicine relaxes blood vessels and can let fluid pool in the legs. Dizziness, flushing and fatigue are also possible. Very rare liver problems usually improve after stopping the drug, but a doctor must guide any change.
People taking higher doses, older adults, and those with heart or liver disease need closer monitoring. Report sudden weight gain, shortness of breath, chest discomfort, or swelling that does not go away.
Do not stop or change amlodipine on your own. A prescriber may adjust the dose or switch medicines if side effects are troublesome. For safety, follow a low-salt diet and keep regular follow-ups with a primary care doctor or a cardiologist.