Polysporin and Neosporin are both over-the-counter antibiotic ointments used on minor cuts, scrapes, and small burns to help prevent infection. The main difference is that Neosporin usually has three antibiotics: bacitracin, polymyxin B, and neomycin. Polysporin usually has two: bacitracin and polymyxin B.
Because Neosporin contains neomycin, it may cause allergic skin reactions in some people. Neomycin allergy is a known issue, especially in people with dermatitis or sensitive skin. Bacitracin can also cause allergy, but neomycin is often the ingredient that makes people compare these two products.
For small, uncomplicated wounds, topical antibiotic ointments may modestly lower the risk of infection. However, the provided sources do not show clear evidence that Neosporin works better than Polysporin for typical minor wounds. The best choice may depend on past skin reactions, allergies, and how the wound looks.
Do not use either product on deep wounds, large burns, serious injuries, or spreading redness without medical advice. Avoid self-medicating if symptoms worsen, and see a doctor or pharmacist if there is swelling, pus, fever, increasing pain, or a rash after use.