Desvenlafaxine: Uses, How to Take & Side Effects

Desvenlafaxine is an antidepressant primarily used to treat major depressive disorder (MDD) in adults. This medication helps improve and stabilize mood for individuals living with this mental health condition.

It works by increasing the levels of serotonin and norepinephrine in the brain to balance these essential neurotransmitters. Many patients begin to notice a significant improvement in their depressive symptoms after just seven days of consistent treatment.

You can find desvenlafaxine at most U.S. pharmacies as a generic tablet or under the brand name Pristiq. A psychiatrist must determine the appropriate dosage and length of treatment based on your specific medical needs.

Woman taking medication

What it is used for

Desvenlafaxine is FDA-approved for the treatment of major depressive disorder (MDD) in adult patients.

This medication helps lift your mood while reducing feelings of distress, intense sadness, fatigue, and lack of motivation. It is also used to help manage recurrent thoughts of death or suicide often associated with severe depression.

For the best long-term results, desvenlafaxine should be taken under the supervision of a psychiatrist. It is most effective when used as part of a comprehensive treatment plan that includes regular psychotherapy.

How to take

The specific dose of desvenlafaxine must always be determined by a healthcare provider; however, the standard starting protocol is usually:

  • 50 mg taken once daily, which a doctor may increase up to a maximum of 200 mg per day.

Dosage adjustments should only occur after a clinical evaluation by a psychiatrist and should not exceed the 200 mg daily limit.

If a dose increase is recommended, it should be done gradually with at least seven days between each adjustment.

Desvenlafaxine extended-release tablets should be swallowed whole with a glass of water and never crushed, chewed, or broken. They can be taken with or without food.

It is best to take your medication at the same time every day to maintain consistent levels in your system. Never stop taking this medication abruptly without consulting your doctor first.

Possible side effects

The most common side effects associated with desvenlafaxine include insomnia, headaches, dizziness, drowsiness, nausea, and dry mouth. Some people also experience excessive sweating, decreased appetite, anxiety, nervousness, irritability, tremors, hot flashes, palpitations, or a decrease in libido.

In most instances, these side effects are most prominent during the first week of treatment and often subside as the body adjusts.

Who should not take it

Desvenlafaxine is not intended for use by children or individuals who are currently pregnant or breastfeeding. It should also be avoided by anyone currently taking venlafaxine (Effexor) or monoamine oxidase inhibitors (MAOIs).

Furthermore, this medication should not be used by individuals with a known allergy to desvenlafaxine or any other ingredients in the formulation.