The MCHC blood test measures mean corpuscular hemoglobin concentration. This index shows the amount of hemoglobin in each red blood cell.
High or low MCHC levels may be linked to anemia, thyroid changes, medication interactions, or excessive alcohol intake. MCHC results should always be reviewed together with other blood test results.
The MCHC blood test is part of a complete blood count (CBC). It is usually assessed along with other CBC values, such as MCV, MCH, RDW, red blood cell count, and hemoglobin levels.
Reference values
The normal MCHC range is typically between 31.0 and 36.0 g/dL, although reference values may vary slightly depending on the laboratory.
Interpreting results
High or low MCHC levels may indicate certain conditions that should be assessed by a healthcare provider together with the other CBC results.
High MCHC
High MCHC is defined as a value above 36.0 g/dL. This indicates that each red blood cell contains a higher concentration of hemoglobin than normal, making the cells appear darker. These cells are referred to as hyperchromic red blood cells.
High MCHC may be a sign of thyroid dysfunction, excessive alcohol intake, or hereditary spherocytosis. Hereditary spherocytosis is a type of hemolytic anemia in which red blood cells become more rounded and may contain a higher concentration of hemoglobin.
Low MCHC
Low MCHC is defined as a value below 31.0 g/dL. It indicates that each red blood cell contains less hemoglobin than normal, making the cells appear paler. These are called hypochromic red blood cells.
Low MCHC may be a sign of:
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Thalassemia
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Iron deficiency anemia
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Sideroblastic anemia
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Heart failure
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Medication interactions
If your MCHC level is abnormal, your healthcare provider will review the rest of your CBC results.
According to the American Society of Hematology, iron-deficiency anemia is diagnosed with blood tests that should include a complete blood count, and iron studies may be ordered when needed. This helps determine the cause and whether treatment is needed.