A Mean Corpuscular Hemoblobin (MCH) is a blood test that measures the average amount of hemoglobin in a blood cell. It is done by adding a reagent to a blood specimen and assessing the color it produces.
MCH is ordered as part of a complete blood count (CBC). It is typically ordered to determine the the type of anemia that a patient has, whether it is hyperchromic, normochromic or hypochromic anemia.
Changes to MCH levels can occur with alcohol intake, thyroid problems and anemia. Therefore, it it important for the doctor evaluate an abnormal MCH result a physical assessment and other test results to determine the most appropriate treatment.
What results mean
MCH can be abnormally high or low, and differences can be caused by:
1. High MCH
In adults, MCH levels that are above 34 picograms is a sign of hyperchromia. The reagent added to the blood specimen will make the red blood cells darker, which can happen as a result of alcohol intake, medications or thyroid problems,
It is also possible to note larger red blood cells than normal. This can happen with megaloblastic anemia, which is caused by a vitamin B12 and folic acid deficiency.
2. Low MCH
MCH levels less than 26 picograms in adults is a sign of hypochromia. Reagents added to the blood specimen will turn the red blood cells paler, which means that there is a reduced amount of hemoglobin in each red blood cell. Low MCH can occur with iron-deficient anemia, and thalessemia (which is a type of genetic anemia).
It is also common to note smaller red blood cells, or microcytic red blood cells. It is important for the doctor to evaluate a low MCH alongside other tests to identify the underlying cause.
Normal MCH levels will vary with age and gender, which can be verified below:
- Newborn: 27 - 31
- 1 to 11 months: 25 - 29
- 1 to 2 years: 25 - 29
- 3 to 10 years: 26 - 29
- 10 to 15 years: 26 - 29
- Men: 26 - 34
- Women: 26 - 34
These values indicate the coloring that a red blood cell has, or how it reacted to the reagent. A red blood cell with become pale with a low MCH, or darker with a high MCH.