Ibogaine is the active compound found in the root of an African plant called iboga. Because it has hallucinogenic properties, it is typically used in some religious ceremonies.
Ibogaine also appears to influence serotonin and dopamine activity in the central nervous system. For this reason, it is sometimes discussed as a potential option for treating dependence on drugs such as tobacco and cocaine.
Ibogaine lacks FDA approval and is classified as a Schedule I controlled substance due to the absence of scientific studies confirming its safety and effectiveness in humans. This strict classification highlights the ongoing uncertainty surrounding its risks and potential benefits.
Potential benefits
Because it has effects that seem similar to serotonin and dopamine, possible health benefits of ibogaine include:
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Helping treat dependence on drugs such as alcohol, crack cocaine, tobacco, cocaine, and morphine, by reducing cravings and withdrawal symptoms;
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Improving fatigue, libido, and mood.
However, since more studies are needed to confirm the safety and effectiveness of ibogaine, ibogaine is classified as a Schedule I controlled substance in the United States and is not FDA-approved for the treatment of any condition, according to the U.S. Drug Enforcement Administration (DEA).
Typical reactions
Like hallucinogenic mushrooms and ayahuasca, ibogaine is considered a hallucinogenic plant. For this reason, chewing the iboga plant or drinking tea made from its root may promote relaxation and can also trigger crying, laughing, and hallucinations, such as seeing or hearing distorted things or things that do not exist.
It is also believed that using iboga may promote “purification” of the mind and body, a sensation of “leaving the body,” and encounters with spirits.
Depending on the amount consumed, the hallucinogenic effects of ibogaine can last up to 24 hours after ingestion.
Side effects
Ibogaine side effects may begin around 30 minutes after ingestion and can last up to 3 hours. They include:
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Agitation;
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Nausea;
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Intense and repeated vomiting;
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Headache;
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Sleepiness;
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Tremors;
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Loss of motor coordination;
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Feeling cold or hot.
In addition, ibogaine use may also cause psychiatric symptoms, cardiac arrhythmia, severe dehydration, epileptic seizures, and sudden death.
Contraindications for use
People with cardiovascular disease, liver disease, or psychiatric disorders such as psychosis, schizophrenia, or bipolar disorder should not use ibogaine.
Ibogaine should not be used together with other drugs, such as alcoholic beverages, marijuana, ecstasy, or cocaine.
In addition, children and people who are pregnant or breastfeeding should also not consume ibogaine.