How to Lower Cortisol (Through Natural Methods & Medications)

Knowing how to lower cortisol is key to reducing the risks of chronic stress and supporting both physical and mental health. Cortisol is a hormone released during stressful situations, and when levels stay high, it can lead to insomnia, weight gain, anxiety, and cardiovascular problems. To help regulate cortisol, there are both natural strategies and medications, which can be especially important for women.

Options include lifestyle changes, psychological support, and, in some cases, medical treatments. Each approach has its own benefits and limitations, so it’s important to have guidance from a healthcare professional to determine the best option.

The treatment plan should be tailored to the cause and the individual’s needs. Both natural approaches and medications require medical evaluation, and ongoing follow-up is essential to ensure safety and prevent complications.

Woman stretching

How to lower cortisol naturally

Natural strategies to lower cortisol work best when practiced regularly and adapted to each person’s lifestyle and preferences. If you have underlying health conditions, medical supervision is strongly recommended.

Some effective natural strategies for how to lower cortisol are:

1. Relaxation and mindfulness practices

Practices such as meditation, deep breathing, or yoga can help reduce the body’s stress response and naturally lower cortisol levels.

2. Regular physical activity

Staying active with moderate exercise helps decrease stress and supports hormone balance, especially in people who struggle with anxiety or depression.

3. Good nighttime sleep

Getting 7 to 9 hours of sleep each night is essential for bringing cortisol back to normal levels. During sleep, the body regulates the circadian rhythm and restores balance, particularly when rest happens in a quiet, interruption-free environment.

4. Healthy diet

Eating a balanced diet is one of the most effective ways to regulate cortisol. Nutrition experts often recommend prioritizing foods like fish, poultry, fruits, vegetables, whole grains, and healthy fats, especially those rich in omega-3 fatty acids.

5. Emotional support and psychosocial interventions

Cognitive therapy, support groups, and emotional regulation techniques have been shown to lower cortisol in people dealing with intense emotional stress.

Medications to lower cortisol

Certain medications are prescribed to treat high cortisol when it is linked to specific medical conditions. These medications should only be used when clearly indicated by a doctor and always with regular monitoring, as unnecessary use can lead to serious complications.

The main medications used to lower cortisol are:

1. Hydrocortisone

Hydrocortisone is mainly prescribed for people with adrenal insufficiency or Cushing’s syndrome. It can be taken orally or given intravenously, always in the dose and schedule directed by a doctor. Its purpose is to replace or regulate natural cortisol production. Regular medical monitoring is crucial to prevent side effects and avoid adrenal crises.

2. CRH inhibitors

CRH inhibitors are experimental drugs designed to block the hormone that stimulates cortisol production. They are being studied for mood disorders and endocrine conditions. Because of potential side effects, they should only be used in research or under strict medical supervision.

3. Metyrapone

Metyrapone lowers cortisol by blocking an enzyme called 11β-hydroxylase in the adrenal glands. It is taken by mouth, and the dose must be tailored individually. While effective in clinical studies, it requires frequent monitoring to track hormone levels and side effects.

4. Aminoglutethimide

Aminoglutethimide blocks the conversion of cholesterol into pregnenolone, disrupting the production of cortisol. Its use has declined due to risks such as adrenal insufficiency, but it may still be prescribed for adrenal tumors or metastasis in some cases.

5. Mitotane

Mitotane works by destroying adrenal cortex cells and is mainly prescribed for adrenal cancer or severe Cushing’s syndrome that does not respond to other treatments. Because of its potential toxicity, the dose must be carefully adjusted with close medical supervision.

How to lower cortisol in women

In women, cortisol levels can fluctuate depending on life stages such as puberty, pregnancy, and menopause. Hormonal and biological differences make personalized management especially important.

Both natural approaches and medications can be adapted to a woman’s needs. Exercise, relaxation techniques, and resilience programs have shown positive results, especially during times of hormonal changes or emotional stress.

Ongoing monitoring is essential to protect hormonal health and support overall well-being in women.

When to see a doctor

It is important to see an endocrinologist or other healthcare professional if symptoms caused by high cortisol persist, worsen, or interfere with daily life.

The doctor will identify the cause and recommend the most appropriate treatment, which may include medication or natural approaches. Early diagnosis and professional guidance are essential to prevent complications related to high cortisol levels.