For a typical uncomplicated vaginal yeast infection, fluconazole is usually taken as a single 150 mg dose. It should not be repeated routinely unless a healthcare professional confirms that another dose or a different schedule is appropriate.
For severe or complicated infections, fluconazole may be prescribed every 72 hours for three doses, usually on days 1, 4, and 7. When yeast infections keep returning, treatment may begin with several doses or a longer course, followed by a maintenance dose once a week for about six months.
How often fluconazole can be taken depends on whether the infection is a one-time episode, a severe infection, or a recurrent problem. Some long-term schedules may be reduced from weekly to every two weeks or monthly, depending on symptoms, relapses, and medical supervision.
Do not self-medicate with repeated fluconazole doses, especially when symptoms do not improve or return frequently. A primary care doctor or gynecologist can confirm the diagnosis, review possible drug interactions and safety concerns, and choose the most appropriate dosing schedule.