When you first start citalopram, it’s common to notice physical or emotional changes before you feel any clear mood improvement. Many people feel a bit off at first, such as more tired than usual, slightly nauseous, or restless. Some also notice their anxiety feels temporarily worse rather than better.
These early effects happen because your brain is adjusting to changes in serotonin levels. During the first one to two weeks, side effects like nausea, headache, dry mouth, sweating, sleep problems, or feeling jittery can appear. For most people, these effects are mild and tend to ease as the body gets used to the medication.
Timing matters. Citalopram does not usually improve mood right away, and it often takes several weeks to feel its full benefit. Early side effects often peak in the first couple of weeks, then gradually fade. Feeling more anxious or unsettled at the beginning does not mean the medication will not work for you.
If side effects feel intense, last longer than a few weeks, or include severe agitation, dizziness, or unusual mood changes, contact a healthcare professional. Do not start, stop, or change the dose on your own, and seek guidance from a doctor or mental health specialist for safe use and follow-up.