Clomid for men is sometimes prescribed to treat hypogonadotropic hypogonadism, a condition that can affect male fertility. However, this is an off-label use, meaning it is not listed as an FDA-approved indication, and it should only be used with a doctor’s guidance.
Clomid works on the hypothalamus and pituitary gland, increasing LH and FSH levels, which are low in hypogonadotropic hypogonadism. Because LH stimulates testosterone production and FSH supports sperm production, clomiphene (Clomid) for men may help bring both testosterone and sperm production closer to normal in some cases.
Hypogonadism can cause symptoms such as lower sex drive, erectile problems, fatigue, and depression. Other medications used to address the problem include testosterone therapy, gonadotropins, and GnRH.
Compared with these options, Clomid for men has two potential advantages. It may help preserve fertility, which does not happen with testosterone therapy, and it is taken by mouth rather than by injection.
Clomid does not solve the problem in cases of congenital hypogonadism or hypogonadism caused by hypothalamus or pituitary tumors, surgery, radiation, or trauma. It also does not work for other causes of infertility, such as retrograde ejaculation or absence of the vas deferens.
If Clomid is being considered for a fertility issue in men, a urologist is the most appropriate specialist to assess male fertility, confirm the underlying cause, and recommend the most suitable treatment.