Yes, antibiotics can sometimes make you feel tired, but this is not common for most people. In many cases, the tiredness felt during antibiotic treatment is more likely related to the infection being treated rather than the medication itself. As the body fights infection, it uses more energy, which can naturally lead to fatigue.
Most commonly prescribed antibiotics do not list fatigue as a typical side effect. One notable exception is vancomycin, which has been associated with feelings of tiredness or weakness in a small percentage of patients. For other antibiotics, studies suggest that fatigue is usually indirect, linked to factors like inflammation from illness, dehydration from side effects such as diarrhea, or the general stress the body experiences while recovering.
Tiredness may appear a few days into treatment and usually improves as the infection clears. If antibiotics cause stomach upset or diarrhea, this can lead to dehydration, which can also worsen fatigue. Severe or sudden fatigue, especially when combined with confusion, weakness, or reduced alertness, is not expected and should be taken seriously.
Antibiotics should only be taken when prescribed and exactly as directed. If tiredness is intense, worsening, or continues after finishing the medication, a healthcare provider should be consulted to rule out complications or the need for a different treatment.