A cortisol cocktail, sometimes called an adrenal cocktail, is a nutrient-based drink usually taken in the morning to support adrenal health and promote steady energy levels.
It’s often made with ingredients like vitamin C (typically from orange juice), sodium (such as sea salt), and sometimes potassium or magnesium. Each component is chosen for its possible role in balancing cortisol levels and maintaining electrolyte function.
Despite its name, the cortisol cocktail is not a medical treatment. It has become popular in wellness communities as a natural way to support the body’s stress response and energy regulation, but it is not backed by clinical research.
What is it used for?
The cortisol cocktail is often used by people who experience fatigue, low energy upon waking, or other symptoms commonly linked to what is called “adrenal fatigue.” Supporters claim that the drink helps replenish nutrients that may be depleted during times of stress, potentially leading to improved mood, focus, and alertness.
However, medical organizations like the Endocrine Society and the Mayo Clinic emphasize that “adrenal fatigue” is not a recognized medical diagnosis. Ongoing fatigue or low energy may point to other health issues, including adrenal insufficiency, which requires evaluation and treatment by a healthcare provider.
How does it work?
The idea behind the cortisol cocktail is based on how its ingredients might support the adrenal glands and cortisol levels. Cortisol is a hormone that follows a daily cycle, rising in the early morning and dropping throughout the day. Drinking the cocktail around the time cortisol peaks—typically within 30 minutes of waking—is thought to align with the body’s natural rhythm.
Vitamin C is involved in hormone production within the adrenal glands and helps protect against oxidative stress. Sodium helps regulate fluid balance and blood pressure, which may be important for people with adrenal-related symptoms. Potassium and magnesium support nerve and muscle function and may play a role in managing stress.
Cortisol cocktail recipe
A typical cortisol cocktail includes:
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1/2 cup of orange juice (for vitamin C and natural sugar)
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1/4 teaspoon of sea salt (as a source of sodium)
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200 to 300 mg of magnesium powder or a potassium supplement (optional)
These ingredients are usually mixed together and consumed shortly after waking. Some variations use coconut water instead of orange juice for added hydration, or collagen powder to include protein.
Is the cortisol cocktail safe?
Most of the ingredients in a cortisol cocktail are considered safe for healthy individuals when used in moderate amounts. However, certain groups should be cautious. People with kidney disease, high blood pressure, or diabetes may be sensitive to the sodium in sea salt or the sugar in orange juice.
There is no scientific evidence that cortisol cocktails improve adrenal function or reduce fatigue. In some cases, taking too much sodium or potassium can lead to imbalances, especially in individuals with preexisting conditions. It’s important to use these drinks as a supplement to a healthy lifestyle, not as a replacement for medical care.
When to see a doctor
Chronic fatigue, low energy, or difficulty sleeping can be signs of an underlying health issue and should be assessed by a healthcare professional. Conditions like adrenal insufficiency, thyroid disorders, anemia, or other metabolic problems may cause similar symptoms and require medical testing and treatment.
While some people may feel better temporarily after using a cortisol cocktail, it is not a cure or a medically approved solution. A proper diagnosis is important to ensure safe and effective care.