To lower creatinine levels, the kidneys need to recover their ability to filter the blood properly, since there is no specific medication that lowers creatinine. Different measures may be needed to restore kidney function, depending on what is causing the creatinine to rise.
If the high creatinine levels are due to acute kidney injury, the cause of that kidney injury must be identified and treated. If the increase is due to chronic kidney failure, treatment needs to focus on controlling risk factors, such as diabetes and high blood pressure.
In more severe cases, when there is severe kidney failure, hemodialysis may be the only treatment able to lower creatinine.
In any case, when creatinine levels are elevated in the blood, it is important to see a nephrologist, who can do a detailed assessment of kidney function, identify the cause of the problem, and start the most appropriate treatment.