Liver Pain: Symptoms, Causes & Treatment Options

Medical review: Dr. Clarisse Bezerra
Family Doctor
May 2022
  1. Infection
  2. Auto-immune disease  
  3. Genetic diseases  
  4. Medication abuse 
  5. Cancer
  6. Fatty liver 

Liver pain is a pain that is felt in the upper right abdomen. It can be a sign of illnesses like infection, obesity, high cholesterol or cancer. Pain can also be felt if the liver is exposed to toxic substances like alcohol, detergents or even some medication. 

Treatment depends on the underlying illness and associated symptoms. Pain can be prevented with up-to-date vaccination, a healthy diet, regular exercise or by avoiding risky behavior like sharing needles or unprotected sex. 

The most common causes of liver pain include:

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1. Infection

The liver can affected by a viral, bacterial or fungal infections, leading to inflammation and changes to functioning. The most common types of liver infections are hepatitis A, B and C, which are viruses that can cause liver pain, joint pain, headache, light sensitivity, light-colored stools, dark urine and yellow skin or eyes. 

How to treat: Treatment should be guided by a liver specialist or family doctor. It will vary depending on the type of infection and may involve the use of antivirals, antibiotics or antiparasitics. You may also be advised to eat light, easy-to-digest meals that are low in fat to help prevent further inflammation. Learn more about the treatment of acute hepatitis.

2. Auto-immune disease  

Auto-immune diseases are characterized by the body's own antibodies attacking their organs. The liver can be affected by autoimmune diseases, which is the case with autoimmune hepatitis, primary biliary cirrhosis and primary sclerosing cholangitis.

Autoimmune hepatitis is a rare disease, in which the body attacks the liver cells. This leads to liver swelling and symptoms like abdominal pain, yellow skin and nausea. With primary biliary cirrhosis, the biliary ducts undergo a gradual destruction by the bodys antibodies, while primary sclerosing cholangitis is characterized by narrowing of the biliary ducts. These conditions can lead to fatigue, itching, scarring and liver failure. 

How to treat: Autoimmune hepatitis is curable with a liver transplant, which is done in severe cases. The disease can otherwise be managed with corticosteroid medication (like prednisone), or immunosuppressents (like azathioprine). Patients should maintain a balanced diet and avoid alcohol and fatty foods. 

The treatment of primary biliary cirrhosis and sclerosing cholangitis usually involves the use of ursodiol. If treatment of these conditions is initiated early on at the onset of symptoms, then it is possible to significantly reduce the progression of disease and prevent scarring. In terminal phases of these conditions, the only treatment available to cure these conditions is a liver transplant. 

3. Genetic diseases  

Pain in the liver area can also be caused by genetic diseases that lead to the accumulation of toxic substances in the liver, like hereditary hemochromatosis (which is associated with increased iron in the liver), hyperoxaluria (which is associated with increased oxalic acid) or Wilson’s disease (which is associated with increased copper). 

How to treat: Hemochromatosis can be treated by avoiding foods that are high in iron, like red meat, spinach or green beans. It is important to follow a diet as recommended by a registered dietitian. With hyperoxaluria, you should reduce your intake of foods with oxalate, like spinach and walnuts. More serious cases will require dialysis or a liver and kidney transplant. Wilson’s disease can be treated by reducing your intake of food that are rich in copper, like mussels, or by taking medications that link to copper (like zinc acetate or penicillamine), which will help to eliminate it through the urine. 

4. Excess alcohol 

Excessive and regular intake of alcohol can increase your risk for developing alcoholic hepatitis. It is associated with strong abdominal pain, nausea, vomiting and loss of appetite. It can cause liver damage if left untreated. 

How to treat: Treatment consists of suspending alcohol intake and using medications like ursodiol or phosphatedilcholine, which reduce liver inflammation and relieve symptoms. More serious cases require a liver treatment. 

5. Medication abuse 

Medication-related hepatitis is caused by exposure to toxic substances, excessive medication use, or even allergic reactions to medications, all which can cause damage in the liver at a cellular level. 

How to treat: Treatment consists of discontinuing the medication or substance immediately. In more serious cases, corticosteroids may be needed until liver function returns to its baseline. 

6. Cancer

Liver cancer can affect hepatocytes, biliary ducts and blood vessels. It is generally very aggressive and can cause abdominal pain, nausea, loss of appetite and yellow eyes. Read more about the common signs and symptoms of cancer.

How to treat: Surgery is usually necessary to remove the affected part of of the liver. Some patients will need chemotherapy or radiation therapy prior to surgery to reduce the size of the cancer. 

7. Fatty liver 

Fatty liver is common in people who are obesie or who have high cholesterol or diabetes. This condition can be asymptomatic, or it can cause symptoms like right-sided abdominal pain, swollen belly, nausea and vomiting. 

How to treat: Treatment for fatty liver consists of regular exercise and a balanced diet made-up of lean meat and vegetables. Understand which foods to eat and avoid for a fatty liver diet. To control cholesterol levels, the doctor may prescribe cholesterol medication. 

Liver symptoms checker 

Report your symptoms below to assess your risk for a liver problem or for another related condition:

  1. 1.Pain in the upper right quadrant of the abdomen
  2. 2.Frequent dizziness or light headedness
  3. 3.Frequent headache
  4. 4.Fatigue for no apparent reason
  5. 5.Bruise easily
  6. 6.Yellowing of the eyes or skin
  7. 7.Dark urine
  8. 8.Loss of appetite
  9. 9.Yellowish, gray or off-white feces
  10. 10.Swollen belly
  11. 11.Itching all over the body

How to prevent liver pain 

Pain in the liver area can be prevented with the following measures: 

  • Drink alcohol in moderation 
  • Avoid risky behaviors, like unprotected sex, using drugs or sharing needles 
  • Ensure you are up-to-date on vaccines that protect you against hepatitis A and B  
  • Use medications moderately, to ensure unintended interactions 
  • Use a mask and protect your skin when using toxic products like paint and detergents  

It is also very important to be physically active on a regular basis and to eat a balanced diet with foods that help to detox the liver, like lemon or artichokes. 

When to go to the doctor

You should go to the doctor when the abdominal pain become intense or persistent, or if it is accompanied by other symptoms, like yellowed skin or eyes, leg swelling, generalized itching throughout the body, dark urine, light-colored stools, weight loss, fatigue, nausea, vomiting or loss of appetite. Learn more about symptoms of liver disease you should not ignore. 

During your appointment, the doctor will perform a physical exam to understand where your pain is coming from. He or she may ask about other symptoms and your dietary habits, and may additionally order testing like an ultrasound, MRI, CT, bloodwork or a liver biopsy. 

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Edited by Tua Saude editing team in May 2022. Medical review completed by Dr. Clarisse Bezerra - Family Doctor in May 2022.
Medical review:
Dr. Clarisse Bezerra
Family Doctor
Dr. Bezerra possesses a medical degree and specializes in family medicine. She is licensed to practice under CRM-CE licence #16976.