Polio Vaccine: Immunization Schedule, Booster & Side Effects

September 2022

The polio vaccine protects children from 3 types of polio viruses that are associated with childhood paralysis. Poliomyelitis is a disease that affects the nervous system and can lead to paralysis of the extremities and dysfunction in motor control. 

The polio vaccine can be taken in an oral form (OPV) or injectable form (IPV), and is usually given in 3 doses during infancy, with a  fourth booster dose given in later childhood. The oral form is made up of a weakened, live polio virus that stimulates an immune response to make antibodies, while the injectable is composed of inactivated strains of the virus. 

The WHO recommends that the first two doses are given prior to 6 months of age, and that the last two are given prior to 5 years. 

Imagem ilustrativa número 2

Immunization schedule

The WHO recommends that vaccination against polio should start at 2 months of age and end before the child turns five. However, interrupted vaccine schedules can continue in adulthood. There are slight variations between the vaccine schedules in USA, Canada and England, which can be observed in the following table: 

First dose2 months2 months8 weeks
Second dose4 months4 months12 weeks
Third dose6 months6 months16 weeks
Booster dose4 to 6 years old18 months3 years old

Although the oral form of the vaccine is a less invasive immunization method and is associated with higher rates of intestinal immunity, the injectable form is the preferred method of administration. OPV poses a minimal risk of OPV-associated paralytic polio as an adverse effect of vaccination, making IPV a safer option. Many countries, like Canada and USA, have exclusively administered IPV as of 1995. 

How to prepare for vaccination 

Administration of IPV does not require any special preparation. Babies who will be taking OPV are advised to hold off on any feeds 1 hour prior, to prevent any possible spitting-up of the vaccine. If the baby vomits or spits-up following the oral vaccine, a new dose is advised to ensure full immunization. 

Contraindications for vaccination 

The polio vaccine should not be administered to children with an immune system weakened by illnesses like AIDS, cancer or post-organ transplant. This population should be assessed on a case-by-case basis, and should following vaccination schedules as indicated by their pediatrician. 

Vaccinations should be delayed if the child is ill on the day of administration, particularly if they have vomiting or diarrhea. These symptoms can interfere the vaccine absorption. Children with a history of polio should also be exempt from vaccination. 

Possible side effects 

The polio vaccine rarely causes with any side-effects, though some children may experience fever, general malaise, diarrhea or headache following vaccination. If the child shows signs of paralysis, which is an extremely rare side-effect, urgent medical attention is strongly advised.

Was this information helpful?

Written and updated by Daisy Oliveira - Registered Nurse, on September of 2022.


  • NATIONAL HEALTH SERVICE UK. NHS vaccinations and when to have them. Available on: <https://www.nhs.uk/conditions/vaccinations/nhs-vaccinations-and-when-to-have-them/>. Access in 12 Sep 2022
  • ALFARO-MURILO, JA et al. The case for replacing live oral polio vaccine with inactivated vaccine in the Americas. Lancet. 1163-1166, 2020
Show more references
  • CENTERS FOR DISEASE CONTROL AND PREVENTION. Child and Adolescent Immunization Schedule. Available on: <https://www.cdc.gov/vaccines/schedules/hcp/imz/child-adolescent.html>. Access in 12 Sep 2022
  • GOVERNMENT OF CANADA. Recommended immunization schedules: Canadian Immunization Guide. Available on: <https://www.canada.ca/en/public-health/services/publications/healthy-living/canadian-immunization-guide-part-1-key-immunization-information/page-13-recommended-immunization-schedules.html>. Access in 12 Sep 2022
  • WORLD HEALTH ORGANIZATION. Poliomyelitis. Available on: <https://www.who.int/teams/health-product-policy-and-standards/standards-and-specifications/vaccines-quality/poliomyelitis>. Access in 12 Sep 2022
Our team made up of medical doctors and health professionals from various fields such as nursing, nutrition, physiotherapy, clinical analysis and pharmacy.